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Aklilu Lemma Institute of Pathobiology: Pioneering Research and Lifesaving Discoveries

Addis Ababa, Ethiopia – The Aklilu Lemma Institute of Pathobiology (ALIPB), a cornerstone of Addis Ababa University, stands as a testament to five decades of groundbreaking biomedical research and vital contributions to public and veterinary health in Ethiopia. Established in 1967 as the Institute of Pathobiology, it was renamed in 2005 to honor the late Professor Aklilu Lemma, whose visionary work transformed a modest parasitology research unit into a premier research institute.

A Legacy of Innovation

ALIPB’s most notable achievements include the discovery of Endod (Phytolacca dodecandra) as an affordable, plant-based molluscicide. This breakthrough has provided a low-cost solution to controlling schistosomiasis, a debilitating disease affecting millions. Endod’s potential was recognized globally when Professor Lemma and his colleague, Dr. Legesse Wolde-Yohannes, were awarded the Right Livelihood Award in 1989.

Scientific Milestones

The Institute has been instrumental in mapping the geographical distribution of schistosomiasis and leishmaniasis in Ethiopia, identifying their snail and sand fly vectors. Another significant achievement is the development of a locally produced DAT antigen for diagnosing visceral leishmaniasis, as well as a radiation-attenuated vaccine against the sheep parasite Dictyocaulis filaria.

Director Prof. Tesfu Kassa currently leads the Institute, continuing its mission of integrating research with educational programs and publishing findings in prestigious local and international journals.

Aklilu Lemma: A Trailblazer in Public Health

Aklilu Lemma, born in 1935, was a pioneering Ethiopian doctor whose early discovery in 1964 revolutionized the fight against schistosomiasis. Observing the lethal effect of Endod suds on freshwater snails during an ecological study, Lemma saw potential for a sustainable, cost-effective solution to a widespread health crisis. His relentless research and advocacy led to the establishment of the Institute of Pathobiology in 1966.

Despite significant scientific validation and promising early results, Lemma faced numerous obstacles, including biases within the international medical community. Undeterred, he forged partnerships with global scientists and donors, establishing an Endod research network across five African countries.

Endod: A Multifaceted Solution

Endod’s efficacy extends beyond schistosomiasis control. It has been explored for other uses, including as a fungicide, a detergent additive, and even a spermicide. Lemma’s collaboration with the University of Toledo resulted in a US patent for an Endod-based molluscicide aimed at controlling zebra mussels in American lakes, opening new avenues for international application and economic opportunities for Ethiopia.

Overcoming Challenges

Lemma’s work highlighted the challenges faced by African researchers, from inadequate facilities to systemic biases. His efforts underscored the importance of building local research capacities and respecting traditional knowledge. By 1986, international workshops and expert group meetings began to address these issues, leading to standardized procedures for Endod’s evaluation.

Continuing the Mission

Today, the Aklilu Lemma Institute of Pathobiology remains a beacon of scientific excellence and a vital player in Ethiopia’s health sector. With ongoing research, community-based projects, and international collaborations, the Institute honors Lemma’s legacy by continuing to seek innovative solutions to public health challenges.

For more information, contact Prof. Tesfu Kassa at tesfu.kassa@aau.edu.et or visit the ALIPB at Addis Ababa University’s Southern Campus.


Contact Information:

  • Director: Prof. Tesfu Kassa
  • Administrative Assistant: W/t Hasabe Getachew
    • Phone: +251-112-135725
  • Address: P.O. Box 1176, Addis Ababa University, Addis Ababa, Ethiopia

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Habtamu Alemu

Habtamu Alemu is a seasoned journalist and the editor-in-chief of Ethio Eyewitness News.

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